Epidemiology Faculty and Staff


Jennifer G.. Mullé  

Updated: 08/27/2014    [update]
Assistant Professor (Graduate Faculty)

Department of:

1518 Clifton Rd NE
Atlanta, GA 30322
tel: (404) 727-3042

PhD, Human Genetics, 2005, Johns Hopkins School of Medicine
MHS, Genetic Epidemiology, 2000, Johns Hopkins School of Public Health
Additional Appointment(s):
Department of Human Genetics
Career Overview:

2005 - 2006       Post Doctoral Fellow, Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences

2006 - 2011       Post Doctoral Fellow, Emory University School of Medicine, Department of Human Genetics  

2011 - present   Rollins Assistant Professor, Emory University Rollins School of Public Health, Department of Epidemiology

Selected Research Projects:

The focus of my research is to identify genetic susceptibility variants that predispose for severe psychiatric illness, and to understand the mechanism by which these variants give rise to disease.  While I study bipolar disorder, autism, obsessive compulsive disorder, and post-traumatic stress disorder, the majority of my work is on the schizophrenia phenotype. Schizophrenia affects 1% of the population worldwide and has a strong genetic underpinning. The primary hypothesis of the lab is that rare variants (1% frequency and lower) contribute in a major way to susceptibiltiy for psychiatric disease. We therefore employ experimental strategies for rare variants detection and analysis, including array CGH for copy number variant (CNV) detection, and targeted next-gen sequencing to identify single base changes in candidate genes. Analysis of these data, and understanding of the downstream consequences of uncovered susceptibility variants, is a major foucs of the lab.

Selected Publications:
Mulle JG
Schizophrenia genetics: progress at last
Current Opinion in Genetics and Development
, 2012.
Kaminsky EB, Kaul V, Paschall J, Church DM, Bunke B, Kunig D, Moreno-De-Luca D, Moreno-De-Luca A, Mulle JG, Warren ST, Richard G, Compton JG, Fuller AE, Gliem TJ, Huang S, Collinson MN, Beal SJ, Ackley T, Pickering DL, Golden DM, Aston E, Whitby H, Shetty S, Rossi MR, Rudd MK, South ST, Brothman AR, Sanger WG, Iyer RK, Crolla JA, Thorland EC, Aradhya S, Ledbetter DH, Martin CL.
An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabilities
Genetic Medicine
, 13: 777-784, 2011.
Bray SM, Mulle JG, Dodd AF, Pulver AE, Wooding S, Warren ST
Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population
, 107: 16222-16227, 2010.
Mulle JG, Dodd AF, McGrath JA, Wolyniec PS, Mitchell AA, Shetty AC, Sobreira NL, Valle D, Rudd MK, Satten GA, Cutler DJ, Pulver AE, Warren ST.
Microdeletions of 3q29 confer high risk for schizophrenia.
American Journal of Human Genetics
, 87: 229-236, 2010.
Moreno-De-Luca D, Steffansson H, Mulle JG, SGENE Consortium, Sanders SJ, Simons Simplex Collection Genetics Consortium, GeneSTAR, Kaminsky EB, Myers SM, Adam MP, Pakula AT, Eisenhauer NJ, Uhas K, Weik L, Guy L, Care ME, Morel CF, Boni C, Salbert BA, Chandrareddy A, Demmer LA, Chow EWC, Surti U, Adrahya S, Pickering DL, Golden DM, Sanger WG, Ashton E, Brothman AR, Gliem TJ, Thorland EC, Ackley T, Iyer R, Huang A, Barber JC, Crolla JA, Warren ST, Martin CL, Ledbetter DH.
Deletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophrenia.
American Journal of Human Genetics
, 87: 618-630, 2010.
Link to this page: http://www.sph.emory.edu/faculty/JMULLE